The number of patients suffering from autoimmune and autoinflammatory diseases is increasing every year. In order to improve approaches to the diagnosis of such diseases, it is necessary to carry out a detailed analysis of the characteristics of the functioning of the patient's immune system using timely molecular genetic research methods and cell analysis. These studies will allow us to take a new approach to understanding the pathogenesis (conditions and mechanisms of onset and progression) of autoimmune and autoinflammatory diseases and thus to develop fundamentally new and effective approaches to their targeted therapy.
The functional state of immune cells is key to understanding their involvement in the pathological process. A new method is currently being developed for this purpose – single-cell transcriptome analysis, which is an assessment of the functional activity of each individual cell.
Researchers at the Autoimmune and Autoinflammatory Diseases Research Laboratory of the WCRC Centre for Personalized Medicine (Unknown, Rare and Genetically Determined Diseases Unit) studied 14 samples of peripheral blood mononuclear cells from patients with autoimmune and autoinflammatory diseases.
To learn more, please read the news of the WCRC for Personalized Medicine.