Research Department for Circulatory Physiology

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Andrey Kozlenok, MD, PhD
Head of Department

On July 1, 2018, five departments of functional testing of Almazov Centre were joined into an interclinical department of functional testing and ultrasound.

The specialists of our Department perform world-class diagnostic studies for children and adults in all areas of CVD, respiratory and nervous system diseases using an integrated approach of traditional procedures and high-tech methods.

Structure:

Major areas

Non-invasive diagnostic methods in patients with ventricular arrhythmias
Atrial fibrillation (stress testing, Holter monitoring with data telemetry via Internet)
Non-invasive electrocardiographic imaging (ECGI)
Risk stratification for sudden cardiac death

New medical technologies and invention patents (jointly with the Electrocardiology Research Laboratory):

Method for diagnosing ischemic ventricular arrhythmias in CAD patients
Method for diagnosing hemodynamically significant coronary artery atherosclerosis.
Differential diagnosis method in wide QRS tachycardia with transesophageal echocardiography
Patient ECG telemetry
Method for diagnosing rare life-threatening rhythm and conduction disorders with long-term ECG monitoring and telemetry
Method for diagnosing ventricular arrhythmias with stress testing
Method for selecting antiarrhythmic therapy with long-term Holter ECG monitoring and telemetry

Participation in State Assignments

From 2015 to 2017, the specialists of the Department took part in the state assignment «Identification of new markers of CVD and endocrine disorders and signs of disadaptation to physical activity based on cardiopulmonary testing and mass spectrometry» (supervised by A. Berezina).

Since 2018, we have been carrying out the state assignment on the «Technologies for diagnosis and effectiveness assessment in the treatment of socially significant diseases using multicomponent microanalysis of exhaled air» (supervised by A. Berezina).

Since 2020, the Department specialists have started a new topic of the state assignment “Centre for remote monitoring of physiological parameters of a high-risk CVD patient and personalized decision-making algorithms based on real-time data.”

Training and education

The Electrocardiology Research Laboratory conducts 4 proprietary training courses each semester:

Clinical electrocardiology and non-invasive arrhythmology
Electrocardiographic diagnosis of cardiac conduction disorders
Algorithms for managing patients with arrhythmias
Holter and longitudinal ECG monitoring

Major publications

Potyagaylo D., Chmelevsky M.P., van Dam P., Budanova M.A., Zubarev S.V., Treshkur T.V., Lebedev D.S. ECG adapted fastest route algorithm to localize the ectopic excitation origin in crt patients. Frontiers in Physiology. 2019. Т. 10. № MAR. С. 183. IF 4,134. Режим доступа: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421262/.

Parreira L., Carmo P., Adragão P., Pinho J., Budanova M., Zubarev S., Cavaco D., Marinheiro R., Carmo J., Costa F., Marques H., Goncalves P. Non-invasive electrocardiographic imaging in patients with idiopathic premature ventricular contractions from the right ventricular outflow tract: new insights into arrhythmia substrate. Journal of Electrocardiology. 2019. Т. 57. С. 69-76. IF 1,363. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/31514015/.

Potyagaylo D., Chmelevsky M., Budanova M., Zubarev S., Treshkur T., Lebedev D. Combination of lead-field theory with cardiac vector direction: ecg imaging of septal ventricular activation. Journal of Electrocardiology. 2019. Т. 57. № Suppl… С. S40-S44. IF 1,363. Режим доступа: https://www.sciencedirect.com/science/article/pii/S0022073619304509.

Bhatt D.L., Steg P.G., Fox K., Ray K.K., Mehta S.R., Leiter L.A., Simon T., Held C., Andersson M., Himmelmann A., Ridderstråle W., Chen J., Song Y., Diaz R., Goto S., James S.K., Parkhomenko A.N., Kosiborod M.N., McGuire D.K., Harrington R.A. et al. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (themis-pci): a phase 3, placebo-controlled, randomised trial. The Lancet. 2019. Т. 394. № 10204. С. 1169—1180. IF 60,392. Режим доступа: https://www.thelancet.com/journals/lancet/article/PIIS0140—6736 (19) 31887-2/fulltext.

Tsyganov A., Wissner E., Metzner A., Mironovich S., Chaykovskaya M., Kalinin V., Chmelevsky M., Lemes Ch., Kuck K.H. Mapping of ventricular arrhythmias using a novel noninvasive epicardial and endocardial electrophysiology system. Journal of Electrocardiology. 2018. Т. 51. № 1. С. 92-98. IF 1,363. Режим доступа: https://www.sciencedirect.com/science/article/pii/S0022073617302388.

Azpilicueta J., Chmelevsky M., Potyagaylo D. ECGI in atrial fibrillation: a clinicians wish list . Journal of Electrocardiology. 2018. Т. 51. № S6. С. S88-S91. IF 1,363. Режим доступа: https://www.sciencedirect.com/science/article/pii/S0022073618304394.

Sohns C., Metzner A., Kuck K. -H., Chmelevsky M. A new algorithm to visualize the individual relationship between electrical rotors from non-invasive panoramic mapping and atrial fibrosis to guide ablation of persistent atrial fibrillation. Clinical Research in Cardiology. 2018. Т. 107. № 5. С. 444-446. IF 4,455. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/29302740/.

Sohns Ch., Lemes Ch., Metzner A., Fink T., Chmelevsky M., Maurer T., Budanova M., Solntsev V., Schulze W., Staab W., Mathew Sh., Heeger Ch., Reißmann B., Kholmovski E., Kivelitz D., Ouyang F., Kuck K.H. First-in-man analysis of the relationship between electrical rotors from noninvasive panoramic mapping and atrial fibrosis from magnetic resonance imaging in patients with persistent atrial fibrillation. Circulation: Arrhythmia and Electrophysiology. 2017. Т. 10. № 8. С. e004419. IF 4,39. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/28790104/.

Sabatine M.S., Giugliano R.P., Keech A.C., Honarpour N., Wiviott S.D., Murphy S.A., Kuder J.F., Wang H., Liu T., Wasserman S.M., Sever P.S., Pedersen T.R., Vishnevsky A., Lukyanov Y., Blokhin A., Kostenko V., Shvarts Y., Markov V., Motylev I., Dronov D. et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. New England Journal of Medicine. 2017. Т. 376. № 18. С. 1713—1722. IF 74,669. Режим доступа: https://pubmed.ncbi.nlm.nih.gov/28304224/.

Wissner E., Revishvili A., Metzner A., Tsyganov A., Kalinin V., Lemes Ch., Saguner A.M., Maurer T., Deiss S., Sopov O., Labarkava E., Chmelevsky M., Kuck K.H. Noninvasive epicardial and endocardial mapping of premature ventricular contractions. Europace. 2017. Т. 19. № 5. С. 843-849. IF 4,045. Режим доступа: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437699/.

Patents and inventions

Patent for invention RU 2611948, issued on 01.03.2017, application No. 2015156622 dated 28.12.2015.
«Method for diagnosing ventricular arrhythmia caused by psycho-emotional factors in patients without structural heart disease»
Authors: Alekseeva D., Treshkur T., Tsurinova E.

Database registration certificate RU 2015620684, issued on 27.04.2015, application No. 2015620205 dated 13.03.2015.
«ICT-FMRC 12-lead long-term arrhythmia database»
Authors: Tikhonenko V., Kozlenok A., Levitin V., Treshkur T., Tulintseva T., Shikhaliev D., Yakushenko E.

Patent for invention RU 2479257 C1 issued on 20.04.2013, application No. 2012105193/14 dated 14.02.2012.
«Method for predicting the effectiveness of myocardial revascularization surgery in CAD patients with high-grade ventricular arrhythmias»
Authors: Tatarinova A., Treshkur T.

Patent for invention RU 2706382 C1 issued on 18.11.2019, application No. 2018141711 dated 26.11.2018.
«Method of combination treatment of ischemic stroke patients in acute and early rehabilitation stages using infrared THz radiation»
Authors: Reukov A., Presnukhina A., Moroshkin V., Naimushin A., Simakov K.

Patent for invention RU 2638462 C issued on 13.12.2017, application No. 2016152449 dated 28.12.2016.
«Treatment method for pneumonia in cardiac patients put on a ventilator or intubated in the early postoperative period»
Authors: Reukov A., Presnukhina A., Moroshkin V., Kozlenok A., Naimushin A.

Utility model patent RU 170934 U1 issued on 15.05.2017, application No. 2016135449 dated 31.08.2016.
«Device for terahertz puncture»
Authors: Bagraev N., Reukov A., Presnukhina A., Moroshkin V., Klyachkin L., Kozlenok A., Malyarenko A., Georgiadi V., Novikov B.

Invention patent RU 2523135 C1 issued on 20.07.2014, application No. 2013116856/14 dated 12.04.2013.
«Therapy method for IS patients with depression of consciousness in the acute period»
Authors: Bagraev N., Kiryanova V., Reukov A., Demchenko E., Barantsevich E., Simakov K., Moroshkin V., Klyachkin L., Malyarenko A., Novikov B.

Utility model patent RU 142744 U1 issued on 10.07.2014, application No.2014108348/07 dated 04.03.2014.
«Electrostatic filter for linear scanning of charged particle beams»
Authors: Kogan V., Lebedev D., Antonov A., Kozlenok A., Moroshkin V., Berezina A.